Registration

Welcome

Opening Lecture

Chiara Di Malta (TIGEM and University of Naples Federico II, Italy)
Exploring novel regulatory mechanisms of lysosomal activity and signaling in health and disease

Cancer biology

Chairs: Anna Maria Porcelli, Paola Defilippi

Aristide Ferrante (Foggia, Italy)
Mitochondrial biogenesis and dynamics are under control of the circadian clockwork

Manuela Sollazzo (Bologna, Italy)
SPARC release upon respiratory Complex I impairment supports survival and migration of ovarian cancer cells

Noemi Ghiglione (Turin, Italy)
Elucidating MLK4 role in pancreatic cancer progression and metabolism

Alessandro Carrer (Padua, Italy)
Cristae remodeling promotes pancreatic cancer progression

Marco Russo (Bologna, Italy)
Multi-omic landscape of micronuclei reveals mitochondrial-dependent inhibition of innate immune response in cancer cells

Short presentations

Debora Gentile (Naples, Italy)
Decoding FAM134B function in colorectal cancer

Alexia Conte (Milan, Italy)
Modelling EGFR activation and endocytosis

Alessia Ruzza (Padua, Italy)
Impact of transglutaminase 2 (TG2) on cancer cell metabolism

Discussion

Coffee break

From cancer mechanisms to therapeutic targeting

Chairs: Barbara Belletti, Pier Paolo Di Fiore

Valentina Rossi (Aviano, Italy)
CDK12/13 inhibition can counteract epithelial ovarian cancer chemoresistance

Raffaele Strippoli (Rome, Italy)
HDAC1/2 control mesothelium/ovarian cancer adhesion impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and ECM protein remodeling

Irene Schiano Lomoriello (Milan, Italy)
The endocytic protein EPN3: a new prognostic marker and potential therapeutic target in metastatic breast cancer

Maria Chiara Mattevi (Aviano, Italy)
Elucidating the role of AREG in luminal breast cancer arising in young women

Katia Cortese (Genoa, Italy)
Mechanisms of trastuzumab-deruxtecan in ERBB2/HER2+ breast cancer: trafficking, cellular responses, and immune modulation

Gian Luca Rampioni Vinciguerra (Rome, Italy)
Fra-2 regulates the cellular stress response to nutrient deprivation in miR-15a downmodulated pancreatic cancer

Short presentations

Michela Sgarzi (Bologna, Italy)
MET hyperactivation prevents perinuclear actin cap alignment: implications for cell metastasis

Junbiao Wang (Camerino, Italy)
Combination of Palbociclib with phage-based anti-HER2 vaccination enhances the anticancer response in a Hormone Receptor‐positive/HER2‐positive breast cancer preclinical model

Barbara Zerbato (Milan, Italy)
Targeting the Hexosamine Biosynthetic Pathway with a novel PGM3 inhibitor, FR054, to suppress tumour growth and enhance chemotherapy sensitivity in cancer

Discussion

Keynote Lecture

Jos Jonkers (Netherlands Cancer Institute, Amsterdam, NL)
Genetic dissection of breast cancer development and therapy resistance in murine models

Dinner

The different facets of organelles and cellular homeostasis

Chairs: Simona Paladino, Carlo Cosimo Campa

Maria Concetta Sergio (Pozzuoli, Italy)
The role of ESCRT complex in SARS-CoV-2 infection

Andrea Conte (Naples, Italy)
Early dysregulation of endosomal pathway driven by Synj1-overexpression: potential impact on Down syndrome neuropathogenesis

Paola Rusmini (Milan, Italy)
Impairment of lysosomal quality control in Huntington’s disease

Diego Medina (Pozzuoli, Italy)
Lack of the lysosomal calcium channel TRPML1 causes renal tubulopathy

Short presentations

Adriana Limone (Naples, Italy)
Targeting RPSA to modulate endosomal trafficking and amyloidogenesis in genetic Alzheimer’s disease

Raffaella Petruzzelli (Pozzuoli, Italy)
Prion Protein promotes copper toxicity in Wilson Disease

Alessandra Palazzi (Naples, Italy)
Functional loss of HIPK2 alters TDP-43 subcellular localization: a new potential mechanism of Amyotrophic Lateral Sclerosis (ALS) pathogenesis

Discussion

Matteo Parri (Nikon)
Innovating your imaging: AXR NSPARC for Confocal Super-Resolution

Coffee break

Intracellular trafficking and cell communication

Chairs: Massimo D'Agostino, Rossella Venditti

Giuseppina Amodio (Salerno, Italy)
Role of the phosphoinositides-phosphatase Synaptojanin-1 in membrane trafficking in the early secretory pathway

Rosaria Di Martino (Naples, Italy)
Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity

Cecilia Battistelli (Rome, Italy)
m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication

Daniela Guarnieri (Salerno, Italy)
Endocytic trafficking and organelle communication in regulating cell response to nanomaterials

Closing Lecture

Giovanni D’Angelo (École polytechnique fédérale de Lausanne, EPFL, Lausanne, CH)
The lipotype hypothesis

Closing remarks and awards

Lunch box

Registration

Lunch box

Welcome

Opening Lecture

Irene Faravelli (Harvard University, Cambridge, MA, USA)
Back to the future: brain organoids to explore development and disease

Tissue repair and regenerative medicine

Chairs: Massimo Gulisano, Irene Faravelli

Valentina Massa (Milan, Italy)
2D and 3D modeling for studying Cornelia de Lange syndrome: lithium beneficial effects

Francesca Furone (Naples, Italy)
Intestinal organoids as a model of celiac disease inflammation

Sara Lovisa (Milan, Italy)
The functional role of Epithelial-to-Mesenchymal Transition during acute intestinal epithelial injury

Eustachio Attico (Modena, Italy)
Biochemical approaches to addressing limbal stem cell deficiency in corneal regeneration

Francesca Agriesti (Foggia, Italy)
Stem cell differentiation and redox metabolism: a focus on osteogenesis

Irene Del Bono (Bologna, Italy)
Unravelling the role of TGF-β family members in cardiomyocyte regeneration

Stefano Boriati (Bologna, Italy)
Glucocorticoid receptor antagonization enhances NRG1-induced cardiomyocyte proliferation and regeneration

Francesca Sacchi (Bologna, Italy)
Corticosteroid receptors exert opposite role in cardiomyocyte proliferative and regenerative capacity

Simona Martinotti (Alessandria, Italy)
Endothelial integrity restoration: a tale of calcium, H₂O₂, and honey

Coffee break

Stem cell and development

Chairs: Massimo Gulisano, Michele Studer

Gianluca Amadei (Padua, Italy)
Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart

Elisabetta Di Fede (Milan, Italy)
p300 modulation in 2D and 3D in vitro models of premature cellular senescence

Arianna Pastore (Naples, Italy)
DNA released from injured cells triggers memory and adaptation in surrounding cells via epigenetic control of IGF-II and 17-β estradiol levels

Chiara Bongiovanni (Bologna, Italy)
Dynamic regulation of bone morphogenetic proteins during cardiac postnatal development

Chiara D’Silva (Bologna, Italy)
Use of neurospheres from 5xFAD mice to investigate how neuroinflammation affects adult neurogenesis in Alzheimer's Disease

Stefania Scalise (Catanzaro, Italy)
TAU pathology and axonal injury are hallmarks of sporadic progressive supranuclear palsy disease in induced pluripotent stem cell-derived dopaminergic neurons

Tânia Alves (Bologna, Italy)
Deciphering the link between the circadian clock and Neural Stem Cells in Alzheimer's Disease

Cecilia Franciosi (Bologna, Italy)
Angelman syndrome: a study on neuronal cultures derived from patients’ ips cells

Giorgia Ruotolo (Milan, Italy)
Uncovering primary cilium defects in Joubert Syndrome using iPSCs derived-Neural Stem Cells

Keynote Lecture

Michele Studer (Université Côte d’Azur, CNRS, Inserm, Institute of Biology Valrose, Nice, France)
Insights into neurodevelopmental diseases: stem cells leading the way

Dinner

Cellular stress and apoptosis

Chairs: Cristina Mazzoni, Nicoletta Guaragnella

Nicoletta Guaragnella (Bari, Italy)
Mitochondrial signaling upon cellular stress: insights into metabolic adaptation and bioenergetic function

Benedetta Caraba (Rome, Italy)
Yeast mutants in decapping-related protein LSM4 are highly sensitive to cellular stress and autophagy triggers

Claudia Bellomo (Naples, Italy)
Celiac disease organoids as a model to study the crosstalk between inflammation and autophagy

Michele Cillo (Pozzuoli, Italy)
FAM134B is a master regulator of ER-phagy during myogenesis

Salvatore Gagliotta (Pozzuoli, Italy)
Investigating mTORC1 and TFEB dynamics in Tuberous Sclerosis using novel human kidney organoid models

Flavia Biamonte and Anna Martina Battaglia (Catanzaro, Italy)
Ferroptosis-mediated crosstalk between oral squamous cell carcinoma (OSCC) cells and neurons in the tumor microenvironment: implication in cancer progression

Giuseppe Caruso (Catania, Italy)
Oxidative stress and inflammation in axial spondyloarthritis: profiling of peripheral blood mononuclear cells

Sara Milioni (Bologna, Italy)
Respiratory complex I deficiency triggers OMA1-mediated integrated stress response and affects lipid homeostasis during glucose restriction

Alessia Marconi (Bologna, Italy)
Light-enhanced cytotoxicity of approved chemotherapeutic drugs

Coffee break

Cellular stress and apoptosis

Chairs: Cristina Mazzoni, Nicoletta Guaragnella

William Blalock (Bologna, Italy)
Enhanced alternative splicing of transcripts encoding the innate immune, stress-activated protein kinase PKR is a prevalent presence in osteosarcoma

Mario Chiariello (Siena, Italy)
A key role for MAPK15 in controlling NRF2 activity and effectively manage cellular oxidative stress

Alfredo Smiriglia (Florence, Italy)
Estrogen-dependent TRX2 activation reverts oxidative stress and metabolic dysfunction associated to steatotic disease

Concetta Bianco (Pozzuoli, Italy)
The role of the MOSPD proteins in ER-mediated contact sites

Giorgia Miloro (Milan, Italy)
Molecular tethers involved in inter-organelle communication controlling EGFR signaling

Dimitri Papini (Florence, Italy)
Targeting RuvBL1/2 ATPase activity blunts chaperones expression and abrogates HSF1-mediated stress response

Closing Lecture

Raffaele Nicastro (Department of Biology, University of Fribourg, Fribourg, Switzerland)
Coping with nutritional stress: convergence of macronutrient scarceness sensing on conserved signaling pathways

Closing remarks and awards